Endep 25mg: Uses, Benefits, Dosage, Side Effects & Safety

Endep 25mg is a prescription medicine. It contains the active ingredient amitriptyline hydrochloride. It is part of a group of medicines called tricyclic antidepressants (TCAs). Endep is mostly prescribed by doctors for depression treatment. Amitriptyline may also be prescribed for other conditions, depending on the patient’s condition and local guidelines.

Endep acts on chemicals in your body that affect your mood and nerve signals . Only take Endep if your doctor tells you to . Therefore, it is important to know about its uses, dosage, side effects and precautions before you start treatment.

What is Endep 25 mg?

Each Endep 25mg contains 25 mg amitriptyline hydrochloride. It is an oral tablet and is available by prescription. Endep 25 is a yellow, film-coated tablet with ‘AP/25’ on one side (Australian official product information).

Amitriptyline acts in part by reducing reuptake of neurotransmitters such as serotonin and norepinephrine. It can therefore affect mood and the signalling of the nerves. It also has a sedating effect, so some patients may feel sleepy after taking it.

Uses of Endep 25mg

Treating Depression

Endep is approved to treat major depressive disorder. As directed by a healthcare professional, it may help to relieve symptoms associated with depressive illness.

Nighttime wetting

In Australia Endep is prescribed for bedwetting when there is no physical cause for the problem. But, its use should be under doctor’s supervision, particularly because age and other medical conditions can affect treatment decisions.

Other Uses

Doctors may sometimes suggest amitriptyline for reasons other than its primary indication. Patients should not start Endep for another condition without consulting with a qualified healthcare professional.

How does Endep 25 mg work?

Endep changes the activity of some transmitters in the nervous system. Specifically, amitriptyline inhibits norepinephrine and serotonin reuptake. This means that these neurotransmitters can hang around longer at nerve junctions. This is thought to be the action responsible for its antidepressant effects.

Amitriptyline also influences several other systems in the body. So it can cause drowsiness and other effects that require appropriate precautions.

How to Use Endep 25mg

Follow your doctor’s instructions when taking Endep. Do not increase the dose, take more tablets or change the treatment schedule without medical advice.

Your doctor will determine the dose that is right for you based on your condition, your age, how you respond to treatment and other medicines you may be taking. Patients should be advised that drowsiness is possible and should be cautious with driving or operating machinery until they know how amitriptyline affects them.

Do not suddenly stop long-term treatment unless your doctor tells you to. A health care professional can help you determine the safest way to change or stop a treatment.

Side Effects of Endep 25mg

As with all medicines side effects can occur with Endep. Possible or common effects can include:

• Sleepiness or drowsiness
• •Dry mouth (xerostomia)
• Constipation 8
• Dizzy
• Blurred vision
• Difficulty urinating
• Appetite or weight changes
• Additional sweating

But not everyone is affected in this way.

In some patients more serious problems may develop. This can impact heart rhythm, blood pressure, mental health and the nervous system. So if you have any unusual heart symptoms, severe confusion, fainting or seizures, serious allergic reactions, or significant change in mood or behaviour, seek medical attention immediately.

Important Warnings & Precautions

Endep isn’t for everyone. Tell your doctor if you have heart or blood vessel problems, liver problems, glaucoma, urinary problems, thyroid problems, seizures, or certain mental health problems.

Important: Do not take Endep with monoamine oxidase inhibitors (MAOIs). The official information says taking amitriptyline with MAOI or too soon after stopping MAOI could cause a serious reaction. The product insert says there should be a 14 day interval when switching from an MAOI.

Antidepressants also carry an important warning about suicidal thoughts and behaviour, particularly in children, adolescents and young adults. Patients and carers should monitor for worsening depression or unusual changes in behaviour and contact the prescriber if these occur.

Endep 25mg and Alcohol use

Alcohol may increase the sedative effects of amitriptyline. So don’t drink alcohol. Talk to your doctor or chemist about drinking alcohol when you’re taking Endep. You should also not drive or use machines if you feel sleepy, dizzy or less alert.

Endep 25mg Product Details & Storage

Endep 25mg is a prescription tablet that is taken orally containing 25 mg amitriptyline hydrochloride. The Australian product information lists ingredients such as lactose monohydrate, microcrystalline cellulose, disodium edetate, sodium starch glycollate, pregelatinised maize starch, colloidal anhydrous silica and magnesium stearate.

Keep this medicine out of the sight and reach of children. Store it as you have been told on the label of the medicine container. Never take prescription medicines from anyone else.

Concluding Thoughts

Endep 25mg is a prescription medicine based on Amitriptyline. It is used mainly for depression. Its action is based on the modulation of serotonin and norepinephrine signalling in the nervous system. However, it should be taken by patients under medical supervision as it can cause drowsiness and other major effects.